You can define two different sets of attributes for every style: One for electronic help formats (HTML Help, WebHelp, Visual Studio Help and eWriter Help) and one for print-style output (PDF, printed manuals, Word DOCX and ePUB and Kindle Mobi eBooks).
If you manage multiple projects that all need to look the same, check out Help+Manual's powerful style repositories. They allow you to share stylesheets between multiple projects and edit the styles for all of them in the same central location. See the Working with Style Repositories chapter for details!
The Format Menu (Reference)